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These include polynuclear hydrocarbon benzo[a]pyrene (a chemical found in coal tar and tobacco smoke), nicotine, and tobacco-specific N-nitrosamines that are linked to cancers of the food pipe, stomach, and mouth

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The nicotine-induced epigenetic alterations reduced expression of mesenchymal peroxisome proliferator-activated receptor- (PPAR), a nuclear receptor that plays a critical role in lung development, homeostasis, and repair

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