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Rodrguez Cetina Biefer H, et al

In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]

The Neelakantan 2018 paper showed strong oral absorption in cell uptake (Caco-2) assays, which is why most research community use is by mouth instead of by injection