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These spaces provide pathways for the nerve roots that travel from the spine to other parts of the body

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Proposed Mechanisms Preventing GABA receptor downregulation Counteracting compensatory NMDA glutamate receptor sensitization Stabilizing benzodiazepine receptor configuration (preventing shift to inverse agonist state) Upregulating GABAergic neurotransmission through pathways distinct from benzodiazepine action itself This tolerance prevention has profound clinical implications

[DOI] [PubMed] [Google Scholar] 56.Turkovic B., Sikiric P., Seiwerth S., Mise S., Anic T., Petek M