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Collectively, these findings suggest that coagulation factors, specifically ADAMTS13 and vWF, represent promising non-invasive biomarkers and potential therapeutic targets in the diagnosis and management of endometriosis, highlighting their role in hypercoagulability and chronic inflammation observed in the disease (70)
While the peptide might clear from the bloodstream relatively quickly, its downstream effects, or the cellular changes it initiates, might persist for longer
VEGF mediates astrocyte activation and increases seizure-related events (181)
Second, the development of new drugs requires additional and more detailed preclinical and clinical studies to determine whether long-term use is biotoxic, whether the drug has adverse effects on other peripheral organs or whether the drug candidate has a real therapeutic effect on the patients
