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Yakunin et al

It can activate the NLRP3 inflammasome and promote the release of inflammatory cytokines, thereby contributing to IR and pancreatic inflammation (42)

In these subjects, long-term NSW was also associated with higher BMI and hormonal changes, confirming that circadian disruption may exacerbate chronic inflammatory-linked conditions 156

The high or moderate increase in ROS seems detrimental for myocardial cells, while its physiological level is necessary for normal cell signaling (123)