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8.5.4.2 Prodrug approaches Designing curcumin prodrugs involves chemically modifying the curcumin molecule to improve its physicochemical properties, such as water solubility and membrane permeability

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These early changes are subtle and easily attributed to placebo effect

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Correlations between individual ratings of fatigue, clinical scores, length of time of illness, and levels of neurochemicals in pgACC and dACC were carried out using Pearsons product moment and were not corrected for multiple comparisons

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