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In some embodiments, administration of a formulation or composition or device described herein, in conjunction with otic surgery, medical device implantation, and/or cell transplantation, reduces or prevents cell damage and/or death (e.g., auris sensory hair cell death and/or damage) associated with otic surgery, medical device implantation, and/or cell transplantation

Baricitinib with the anti-TNF factor antibody ADA (NCT04870203) and others are registered in the following clinical trials (NCT05246293, NCT05238896, NCT05153200, NCT04985435)

Besides, the treatment of berberine can reduce the activity of ecto-nucleoside triphosphate diphosphohydrolase (NTPDases) and 5-nucleotidasein the cerebral cortex and hippocampus (de Oliveira et al., 2019)

4.89 10 6 cm/s in the control group), but it had no influence on the penetration of the targeted 3-PLG-ibu-A-GSH (10.99 10 6 cm/s vs