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This had no impact on the peer review process and the final decision

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Subsequent peer-reviewed preclinical studies have examined its use as a tool compound for investigating NNMT enzyme activity in adipose, liver, and skeletal muscle cell-based research models under controlled laboratory conditions

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The optimal number of clusters was determined by finding the global minimum in the Kelley penalty graphs (Supplementary Figures S18, 19)

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Animal care was in compliance with SOPs of Pharmacology Animal facility

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Differences between samples were assessed using independent two-tailed t-tests or analysis of variance (ANOVA)

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