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doi:10.1016/j.joms.2019.05.003 Meier S, Haschke M, Zahner C, et al

The cause is unknown and diagnosis may take several visits to doctors and is predominately based around excluding other possible causes for the symptoms like and infection as there is no conclusive test to prove someone has interstitial cystitis

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In some embodiments, an otic high viscosity formulation or device is administered in combination with an external otic intervention, e.g., a surgical procedure including but not limited to middle ear surgery, inner ear surgery, typanostomy, cochleostomy, labyrinthotomy, mastoidectomy, stapedectomy, stapedotomy, endolymphatic sacculotomy, or the like

Fed state pH in the stomach rises above 4, which slows acid hydrolysis but also changes gastric emptying rate