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Antimicrobial Preservative Use in Parenteral Products: Past and Present

These studies focus on molecular mechanisms and pathway mapping, not clinical use

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Mice were group-housed (25 animals per cage) and acclimatized until reaching 10 weeks of age prior to surgical procedures

Hypoxia increases mitochondrial ROS formation and leads to enhanced infiltration of activated inflammatory cells (71)

In a similar study, mice given proanthocyanidin-rich grape seed extract for 710 days before receiving doxorubicin injections were almost completely protected from the drugs toxic effects on blood chemistry and heart tissue