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Glutathione synthase adds glycine to -GC resulting in glutathione formation

A novel, species-specific class of uncompetitive inhibitors of gamma-glutamyl transpeptidase

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The fundamental mechanism is the activation of phase II detoxification enzymes or antioxidase controlled by Nrf2/ARE, including the expression of NAD(P)H quinone dehydrogenase 1 (NQO1), GPX, and superoxide dismutase (SOD) (Truong et al., 2014)

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