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But it should be noted that at meantime of brain protection, BBB also excludes more than 98% of small-molecule drugs and all macromolecular therapeutics from access to the brain

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Next, the irreversible transfer of a methyl group from SAM to GAA is catalysed by the enzyme SAM:guanidinoacetate N -methyltransferase ( Reference Wyss and Kaddurah-Daouk 17 )

Tumor cell metabolism: cancer's Achilles' heel