However, there is no evidence that maternal homocysteine is a causative factor in neonatal brain development but measurement of maternal homocysteine concentration may provide an insight into the efficiency of the methionine cycle and provision of methyl groups (one carbon metabolism) during pregnancy
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110 - 116 Copyright Copyright The Authors 2008 Over the last few years, increasing evidence has shown that hyperhomocysteinaemia is an independent risk factor for the development of CVD ( Reference Wyss and Schulze 1 , Reference Harbor-Gonalves, Vaz and Bezzi 2 ) and may be associated with neurodegenerative disease ( Reference Obeid and Herrmann 3 , Reference Bender, Koch and Elstner 4 ) , diabetes ( Reference Wijekoon, Brosnan and Brosnan 5 ) and end-stage renal dysfunction ( Reference Taes, Delanghe and De Vriese 6 , Reference Taes, Delanghe and De Bacquer 7 )
The key difference is concentration
Fixed drug eruption induced by indapamide: cross-reactivity with sulfonamides
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