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In experimental autoimmune encephalomyelitis (a model of multiple sclerosis), berberine reduces the permeability of the blood-brain barrier and inhibits the activity of matrix metalloprotease 9 (MMP-9) in the cerebrospinal fluid and the brain of model mice (Ma et al., 2010)

Some studies suggest it may help with depression and anxiety due to its role in neurotransmitter balance

As a second example, the Promia success story (see Box 4-3) illustrates three important elements of the SBIR program at Navy

Doctors switch to ultrasound imaging because it provides far more accurate information than blood math

doi: 10.1038/srep21224 (2016)

However, their activity consumes significant amounts of NAD + , leading to a depletion of cellular NAD + levels and impacting energy metabolism and cell survival 58