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10.1186/s12951-022-01407-8 9

While scientific backing is limited, it is widely used as a natural aid

The concern with chronic supratherapeutic exposure is not acute toxicity but unknown long-term effects on angiogenic and growth-factor pathways

SinghKConnorsSLMacklinEASmithKDFaheyJWTalalayPet al

Typical research-protocol dosing is 200500 g one to three times daily, subcutaneous or intramuscular

In the cortex, both the percentage area of A plaques and the levels of soluble A 140 , A 142 , and A oligomer were significantly reduced in the combination group than in the (-)-Vestitol group ( P = 0.0391, 0.0041, 0.0471, and 0.0425, respectively) and the Salviolone group ( P = 0.0166, 0.0005, 0.0115, and 0.0132, respectively) (Fig