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23 In addition, for many decades increased immunostaining with antibodies against glial fibrillary acidic protein (GFAP) has been regarded as a universal molecular marker of astrocyte reactivity

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It formally identified these compounds as presenting potential safety risks and rendered them entirely ineligible for routine compounding

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Emerging evidence suggests it may reduce inflammatory markers like high-sensitivity C-reactive protein (hsCRP), though whether this represents direct anti-inflammatory action or secondary benefits from metabolic improvements remains under investigation