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Transcobalamin II receptor polymorphisms are associated with increased risk for neural tube defects

8,795 The metal requirement and metal specificities of the R2 subunits have been shown to differ among the class I subclasses, with class Ib of particular note here, since class Ib R2 enzyme is truly cambialistic, forming active enzymes with both dinuclear Fe/Fe and Mn / Mn cofactors (Figure 33)