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Moderate caloric restriction (15-20% below maintenance) supports AOD-9604 protocols without triggering metabolic adaptation or excessive muscle loss

(3) Researchers have investigated whether NNMT inhibition might represent a novel approach to modulating energy expenditure and metabolic health

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SURPASS-CVOT (N=13,165) noninferior on 3-point MACE (HR 0.92), significant on 4-point MACE (0.88) and all-cause death (0.84): Heerspink SURPASS-4 kidney post-hoc