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TREK-1 channels are "leak" channels that maintain resting membrane potential and regulate neuronal excitability

Glucose 6-phosphate dehydrogenase (G6PD) deficiency is a posible risk factor for the development of preeclampsia

Inflammatory factors induce vascular remodeling, endothelial cell dysfunction, extracellular matrix deposition, mesangial proliferation, podocyte, and tubular death, and in addition, glomerular basement membrane (GBM) thickening, and glomerulosclerosis are hallmarks of DKD [9, 26]

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Common trial findings include slight reductions in fat mass, small improvements in body weight and often better preservation of lean mass during calorie restriction