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10.1038/nature13020 Summary Keywords hepatocyte transplantation, small molecule, cell-based therapy, induced pluripotent stem cell, instant blood-mediated inflammatory reaction Citation Shi H, Ding Y, Sun P, Lv Z, Wang C, Ma H, Lu J, Yu B, Li W and Wang C (2024) Chemical approaches targeting the hurdles of hepatocyte transplantation: mechanisms, applications, and advances