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Since 90% of the bodys serotonin originates in the gut, modulating enteric serotonin production could influence central serotonergic tone through vagal afferents that relay gut signals to brain serotonin-producing raphe nuclei

Creation of a claudin-2 binder and its tight junction-modulating activity in a human intestinal model

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Supporting these pathways with a more bioavailable formulation may enhance the breadth of downstream wellness benefits