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Premedication was administered using 3 mg/kg of xylazine, followed by general anesthesia with 50 mg/kg of ketamine

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Plant Cell Environ 43:11751191 Acknowledgements The author thanks the French Agence Nationale de la Recherche HIPATH project (ANR-17-CE20-0025) and the Institut Universitaire de France (IUF) for financial support

Based on serial transgenic mouse models, it has been confirmed that IRF7, IRF8, and IRF9 were anti-hypertrophy factors that are consistently down-regulated in cardiac hypertrophy and heart failure

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84 A phase I trial assigned approximately 50 participants with a BMI between 30 and 40 kg/m 2 without diabetes to single ascending dose (SAD), multiple ascending doses (MAD) or placebo