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When the mitochondrial membrane is enriched in cholesterol, it decreases the activity of the GSH transporter system [57]

Oxidative stress responses clarified the functioning of central principal switches like nuclear factor (NF)-B (NFB) or the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway (Sies, 2015

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liver enzyme alterations are very frequent in PAC treated patients, even at routine dosage