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Patients with unipolar depression manifested increased amygdala activation in response to negative facial expressions, whereas patients with bipolar depression demonstrated a greater amygdala response to positive facial expressions (147)

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Preclinical Observations Findings observed in murine studies include: Endurance capacity: Increased treadmill running time and distance Mitochondrial function: Enhanced respiration and ATP production in muscle Cardiac metabolism: Improved fatty acid utilization in models of heart failure Renal function: Reduced mitochondrial dysfunction and inflammation in aging kidney models Metabolic profile: Improved glucose handling in metabolic syndrome models These results are limited to animal models using intraperitoneal injection

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