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Enzymatic glutathionylation reactions are tightly controlled and highly specific and are considered a major post-translational modification that occurs in response to fluctuations in local redox environments

PMID: 22330318

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In the CNS, laminin deficiency leads to BBB breakdown, characterized by reduced pericyte coverage, leukocyte extravasation, and altered expressions of VE-cadherin, claudin-5, and occludin, underscoring laminin's role in maintaining BBB integrity [51, 66,67,68]

doi: 10.1161/CIRCULATIONAHA.108.835223 5 HortonWBBarrettEJ