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Tissue-local accumulation at injury sites is plausible but not extensively characterised

For Unopened Vials: No, Not Necessarily

During experiments, when using frozen peptide products, vials and test tubes need to be brought to room temperature in a drying box filled with fresh desiccant before opening the cap

According to the randomization procedure, Group 1 was assigned to the novel methylcobalamin nasal spray (NASO B12) and Group 2 was assigned to methylcobalamin oral tablet for the treatment of vitamin B12 deficiency during the study period of 15 days [Figure 1]

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Oral administration results in lower systemic availability due to digestive enzymes, though the peptides stability allows local gastrointestinal effects at high concentrations which is why oral delivery is often preferred for BPC-157s gut healing applications