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Nicotine activation of nAChRs gives rise to acute analgesic effects in animal models and humans [11]

In the latter half of the century, opium smoking became popular in the artistic communities of Europe

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higher alcohols derive from amino acid degradation (e.g., leucine to isoamyl alcohol), and esters form via alcohol acyltransferase-catalyzed reactions between alcohols and acyl-CoA

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