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5 Conclusion This systematic review and meta-analysis indicate that sublingual and oral vitamin B12 administration provide efficacy comparable to intramuscular injection in improving serum cobalamin levels and reducing hyperhomocysteinaemia

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doi: 10.1186/s12890-021-01575-7 128 ieMRSue-ChuMHelvikASSteinsvagSKSteinsbekkSThorstensenWM

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In some embodiments, the otic formulation or composition comprises about 13% by weight of the cholesterol