It can deliver glutathione to the cells efficiently, which improves the utilisation efficiency of glutathione in the body, allowing its physiological functions such as antioxidant and detoxification to be better performed
Additionally, the role of non-classical ferroptosis regulators (e.g., FSP1, DHODH, and GCH1/BH4) in DN is largely unexplored
This property is essential for the compound to exert its metabolic effects
She exhibited low autonomic activity, diminished primitive reflexes, yellowish skin, muscular hypotonia, and poor peripheral blood circulation
& Siddiqui, K
Finally, the C-terminal Neh3 domain is another transactivation domain that recruits chromo-ATPase/helicase DNA-binding protein 6 (CHD6), functioning as an NRF2 transcriptional coactivator [153] (Fig