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High, prolonged cortisol feeds back to the hypothalamus and pituitary in ways that suppress gonadotropin-releasing hormone (GnRH) pulses

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Handle using appropriate laboratory protective equipment

The proximal tubules demonstrate vacuolar degeneration, interstitial edema, and protein deposition 87

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It also has been described that -glutamylcysteine, the intermediate of GSH biosynthesis, is able to act as a Gpx1 cofactor in mitochondrial H 2 O 2 detoxification, mimicking the physiological properties of GSH (Quintana-Cabrera et al., 2012)