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Necroptosis of erythrocytes relies on the RIPK1 (receptor-interacting serine/threonine-protein kinase 1)/RIPK3 (receptor-interacting serine/threonine-protein kinase 3)/MLKL (mixed lineage kinase domain-like pseudokinase), similarly to nucleated cells

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For subsequent refills or if you were previously on the medication, follow-ups are required every 6 months