Topical application without delivery enhancement deposits the molecule on the outermost stratum corneum (10 to 20 micrometers thick), which is the wrong tissue for the receptor biology to engage 2
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10.1016/j.neurobiolaging.2014.09.013 50 GugliandoloA.BramantiP.MazzonE
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These include fetal neurons (Barker et al., 2013), embryonic-derived neural stem cells (eNSCs) (Uchida et al., 2000