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doi:10.1007/s12263-014-0435-1 [28] Davis SR, Stacpoole PW, Williamson J, et al

10.1039/D0FO03199B 193

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It doesnt enter systemic circulation

GSH synthesis catalyzed sequentially by two cytosolic enzymes, -glutamyl-cysteine synthetase (GCS) and GSH synthetase is part of virtually all cell types, and the liver is the major GSH producer and exporter