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Intriguingly, appropriate linkers differed among the dimeric macrocycles: (1) aML5 yielded the highest activity when dimerized by PEG3 (aML5-PEG3) and was nearly inactive when dimerized by the other two linkers (Fig

[PubMed] [Google Scholar] 12.Holm EA

the leucine-rich repeat kinase 2 (LRRK2) protein induces ferroptosis by acting on the System Xc/GSH/GPX4 pathway (51) and the m6A demethylase fat mass and obesity-associated protein can promote ferroptosis via the p53/SLC7A11 axis (39)

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The middle button shows a stick model of this helix, with the backbone chain drawn as a heavy black line and the hydrogen bonds as dashed maroon lines