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Some patients benefit from splitting the dose into two injections per week (e.g., Monday/Thursday) to reduce the peak-to-trough variation

Results Using 53 search terms related to digital health and the ten selected rare diseases (see Supplementary Table 1), a total of 8373 clinical trial records and publications were initially retrieved from Clinicaltrials.gov, the ICTRP, Cochrane, PubMed and Web of Science

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