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Chronic exposure to UV radiation induces the activation of select skin immune cell subsets such as retinoic acid receptor-related orphan receptor gamma t (RORt)differentiated innate lymphoid cells (ILCs) and T lymphocytes, resulting in a perturbation of local cytokine landscape characterized by an enrichment of IL-22 and IL-17A associated with the proliferation of mutated keratinocytes (KCs) [120]

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