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Results from the co-treatment with Fer1, a ferroptosis inhibitor, and ZVAD, an apoptosis inhibitor, indicate that RSL3 effects were reversed by Fer1 but not by anti-apoptotic ZVAD

Since the synthesis and expression of GPx4 are regulated by various cellular processes, targeting GPx4 may constitute a promising strategy for the induction of ferroptosis and the promotion of cancer cell death in treatment-resistant cancers (Lee and Roh 2023)

10.1002/ame2.12387 22 ChengY.SiY.WangL.DingM.YuS.LuL.et al (2021)

Santos, A., Magro, D

Kidney immunology from pathophysiology to clinical translation