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Foley RW, Shirazi S, Maweni RM, et al

When pores are more receptive, skincare ingredients such as hydrating agents, antioxidants, and soothing compounds can reach deeper layers of the skin barrier

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Another limitation is discomfort and pain associated with repeated drug injections, which would make patients skip or in worst case he or she may cease the clinical treatment 14

Sources: Johansen PB, et al