Mitoma, H., Hadjivassiliou, M
Post-translational histone modifications (PTMs) are recognized by specialized protein domains: chromo-domains bind methylation, bromo-domains detect acetylation, BCRT domains recognize phosphorylation, and PHD domains interact with methylation marks
To overcome these problems, various halogenated derivatives (e.g., chlorinated or boronated PBN), alkylated derivatives having a lipophilic tail (e.g., those with dodecyl chains), bifunctional derivatives (e.g., GS-PBN, Mito-DEPMPO, 5-ChEPMPO, DECPO, and 4-HMDEPMPO), conjugates with drugs or targeting molecules (such as PEG or heparin, that both can cross the BBB), dimers, and cyclodextrin polymers have been developed in the last few years (Han et al., 2009
Scientifically, they are known as GHK-Cu [4]
M.PepineC
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