ITCs are electrophilic compounds that have been shown to activate phase II detoxification enzymes, including glutathione S -transferases (GSTs), in several organisms 24,25,26
Although there are no case reports or case series suggesting increased risk of paracetamol-related toxicity in people with Gilberts syndrome, a number of controlled studies have investigated the effect of this reduction in UGT activity on paracetamol metabolism
It binds to toxins and heavy metals, facilitating their elimination from the body
Concomitantly, we measured increased pyruvate levels in mutant compared to control cells (Supplementary Fig
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The authenticity of the remaining cell lines was not tested