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13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig

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Mintun MA, Lo AC, Duggan Evans C, Wessels AM, Ardayfio PA, Andersen SW, et al

Jhun, J

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Therefore, future research must prioritize improvements in longitudinal studies to address differences between rodent and human autoimmunity progression during the asymptomatic first and second phases of T1D pathogenesis