Evidence hierarchies distinguishing strong human clinical data from preliminary animal studies
Godwin DA, Michniak BB
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More recently, a huge umbrella review conducted on more than 12,800,000 subjects from 29 meta-analyses demonstrated a robust statistical association between adherence to the MedDiet and risk reduction of cardiovascular and neurodegenerative diseases, cancer incidence and diabetes (68) (Figure 3)
One explanation is the thought that curtailing IGF-1 levels increase the expression of other genes that are involved in stress resistance, particularly oxidative damage
The optimal schedule depends on your goals