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The Surgeon General reports that electronic cigarettes have the potential to benefit adult smokers who are not pregnant if used as a complete substitute for regular cigarettes and other smoked tobacco products

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Nicotine is able to influence dopamine's activity by directly binding nAChRs on dopaminergic projections sourced in the VTA as well as by regulating glutamate and GABA activity, which excites and inhibits dopaminergic activity, respectively (94)