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In 5xFAD mice, selective neuronal loss is found in cortical layer 5 (L5), without affecting the overall neuron number in the total frontal cortex and hippocampus, and this correlates with the reduced anxiety-like behavior (Vrkonyi et al., 2022)

doi: 10.1038/s41598-022-17929-y 223

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Those white blood cells, called neutrophils, will try to destroy the uric acid crystals

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