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Before administering the intervention, the mice were given swimming treatment for 15min to increase the stress state

This suggests that the extra carbohydrate intake in multiple times a day particularly damages -cells

IGF-1 and growth hormone receptor activation controls confirming that AOD-9604 does not engage the classical hGH receptor or elevate IGF-1, distinguishing its mechanism from full-length growth hormone in cell-based reporter systems

Prez de la Lastra et al., 2021)

Many therapeutic agents are either adrenergic activators or inhibitors