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Biobehav Rev

The members of the UGT1A subfamily have been found to be identical in their terminal carboxyl 245 amino acids, which are encoded by exons 25

doi: 10.1136/gutjnl-2015-309957 177 BarreaLAnnunziataGMuscogiuriGLaudisioDDi SommaCMaistoMet al

2 Previously described as a harmless metabolic byproduct, it is now implicated in the pathogenesis of cardiovascular disease (CVD), chronic kidney disease (CKD), and other metabolic syndromes

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Additionally, thioredoxin-1, a core component of the thioredoxin system, also contributes to these protective effects by maintaining cellular redox balance (237, 238)