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During the sequential oxidation of hypoxanthine to xanthine and then to uric acid, xanthine oxidase (XO) incompletely reduces O, generating O 2 and HO [128]

Y.ZengZ.et al

Evaluation of compound 2 stability under the biochemical assay conditions with recombinant TGR TGR assay solutions (1 ml each) were prepared as described in the main manuscript

This stable, bioavailable form of glutathione supplies the bodys master antioxidant directly

The double increase in Asc in ischemic tissue compared to healthy tissue indicates increased ROS formation under ischemic conditions and confirms the role of oxidative stress in ischemia

EC 1.11.1.9 Glutathione Peroxidase (GSH-Px