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First, each test mouse was habituated to the empty chambers for 5 min, 1 h before the sociability test

Schmidt M, Scheulen ME, Dittrich C, Obrist P, Marschner N, Dirix L, et al

Aceves, S

Abstract Despite advances in immunotherapy, triple-negative breast cancer (TNBC) remains a major therapeutic challenge owing to its marked aggressiveness, low immunogenicity, and limited responsiveness to immune checkpoint blockade (ICB)

The injection and oral cycling approach produces more consistent and sustained results

The maintenance frequency approach where intensive initial treatment transitions to reduced ongoing application (2-4 times weekly) provides middle ground sustaining benefits while minimizing costs and commitment intensity