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Migraine involves interactions within the central and peripheral nervous systems, with significant activation and sensitization of the trigeminovascular system (TVS) in pain generation and transmission

Yang Z, Du X, Wang A, Zhao Y, Xia Y, Shi L, et al

D., Elliot, T., Cree, M., Wolf, S., Sanford, A., & Wolf, R

Modification strategies such as optimizing cell culture conditions, genetically modifying source cells, or refining Exos isolation techniques can increase the yield of EVs [237, 238]

The experimentation was done in 3 replications with 5 insects of a particular type in each petri plate and continued for 72 h After Feeding (HAF) (Figure S5) 22

The body then eliminates these smaller fragments naturally