You can get small amounts of ALA through food, and nutrients like vitamin B12 and acetyl-L-carnitine (ALCAR) have shown promise in human studies, particularly for diabetic neuropathy
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However, in practice, doseresponse patterns are significantly complicated due to many other interactions with (i) multiple targets (receptors) of different affinities to the active compound, (ii) other regulatory proteins or mediators in the networks involved in the adaptive stress response, (iii) feedback down regulations in the molecular signaling pathways, and/or (iv) metabolic transformation of active ligands into metabolites, a secondary ligand, which have different affinities to various receptors of the adaptive stress response [69]
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Most human studies used intravenous administration
